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von der Lühe, Moritz
Position: PhD Student

Moritz

Email: 

Phone:  +49 3641 948180
Fax:      +49 3641 948252

Room 118, Lessingstr. 8

 

Description:

Moritz was born in Göttingen in 1987. After his A-Levels in Homberg/Efze and civil service he started studying chemistry at the Friedrich Schiller University in Jena. He finished his diploma thesis on Polymer@Fe3O4 hybrid particles in January 2014 and since then he is working as a PhD Student on core-shell hybrid materials. In his free time he enjoys reading and playing trombone.

Vita

since 02/2014:     

PhD Student "Protein Corona Formation in Core-Shell Hybrid Materials"

Funding: DFG SPP1681

01/2014:     

Diploma thesis "Polydehydroalanines as Coatings for Fe3O4@Polymer Hybrid Particles"

2007 - 2013:    

Diploma studies in chemistry, Friedrich-Schiller-University Jena, Germany
2006:     
Abitur (A-Level)

Research

Funding: DFG SPP1681

Fe3O4@Polymer hybrid particles

The application of nanoparticles into biological systems leads to the formation of a protein corona, which influences the biocompatibility and interaction of the particles with the surrounding environment. The influence of surface charges on the corona formation will be investigated. By deprotection of the functional groups of poly(2-tert-butoxy-carbonylaminomethylacrylate) (PtBAMA), polycationic (poly(amino methylacrylate), PAAMe), polyanionic (poly(tert-butoxycarbonylaminoacrylic acid), PtBAA) or even polyzwitterionic materials (polydehydroalanine, PDhA) can be obtained.

These materials are then used to coat the Fe3O4 nanoparticles. The influence of the different charges and molar masses on the corona formation will be determined.

Publications

6) Eckardt, O.; Pietsch, C.; von der Lühe, M.; Brauer, D. S.; Schacher, F.H.; "Well-Defined SiO2@P(EtOx-stat-EI) Core-Shell Hybrid Nanoparticles via Sol-Gel Processes" Macromol. Rapid Commun. 2016, 37,337-342

5) Rudolph, T.; von der Lühe, M.; Hartlieb, M.; Norsic, S.; Schubert, U. S.; Boisson, C.; D'Agosto, F.; Schacher, F. H.; "Toward Anisotropic Hybrid Materials: Directional Crystallization of Amphiphilic Polyoxazoline-Based Triblock Terpolymers" ACS Nano 2015, 9, 10085-10098

4) C. Gräfe, A. Weidner, M. v. d. Lühe, C. Bergemann, F. H. Schacher, J. H. Clement, S. Dutz, "Intentional Formation of a Protein Corona on Nanoparticles - Serum Concentration Affects Protein Corona Mass, Surface Charge, and Nanoparticle-Cell Interaction", Int. J. Biochem. & Cell Biol. 2015, doi: 10.1016/j.biocel.2015.11.005

3) von der Lühe, M.; Günther, U.; Weidner, A.; Gräfe, C.; Clement, J. H.; Dutz, S.; Schacher, F. H.; "SPION@polydehydroalanine hybrid particles" RSC Advances 2015, 5,31920-31929

2) Weidner, A.; Gräfe, C.; von der lühe, M.; Remmer, H.; Clement, J. H.;  Eberbeck, D.; Ludwig, F.; Müller, R.; Schacher, F. H.; Dutz, S.; "Preparation of Core-Shell Hybrid Materials by Producing a Protein Corona Around Magnetic Nanoparticles" Nanoscale Res. Lett. 2015, 10, 992

1) Rudolph, T.; Crotty, S.; v. d. Lühe, M.; Pretzel, D.: Schubert, U. S.; Schacher, F. H.; "Synthesis and Solution Properties of Double Hydrophilic Poly(ethylene oxide)-block-Poly(2-ethyl-2-oxazoline) (PEO-b-PEtOx) Star Block Copolymers", Polymers 2013, 5, 1081-1101