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Funding: DFG SPP1681

Fe3O4@Polymer hybrid particles

The application of nanoparticles into biological systems leads to the formation of a protein corona, which influences the biocompatibility and interaction of the particles with the surrounding environment. The influence of surface charges on the corona formation will be investigated. By deprotection of the functional groups of poly(2-tert-butoxy-carbonylaminomethylacrylate) (PtBAMA), polycationic (poly(amino methylacrylate), PAAMe), polyanionic (poly(tert-butoxycarbonylaminoacrylic acid), PtBAA) or even polyzwitterionic materials (polydehydroalanine, PDhA) can be obtained.

These materials are then used to coat the Fe3O4 nanoparticles. The influence of the different charges and molar masses on the corona formation will be determined.